STRING 9.05 






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This is the confidence view. Stronger associations are represented by thicker lines.

 
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Your Input:
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor; Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis (427 aa)
(Homo sapiens)
Predicted Functional Partners:
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
0.999
MED1
mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the re [...] (1581 aa)
0.999
NCOA1
nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear recept [...] (1441 aa)
0.999
NCOR1
nuclear receptor co-repressor 1; Mediates transcriptional repression by certain nuclear recepto [...] (2440 aa)
0.999
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (536 aa)
0.999
NCOA2
nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear r [...] (1464 aa)
0.999
CREBBP
CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation [...] (2442 aa)
0.995
NCOA3
nuclear receptor coactivator 3; Nuclear receptor coactivator that directly binds nuclear recept [...] (1424 aa)
0.993
SNW1
SNW domain containing 1; Involved in vitamin D-mediated transcription. Can function as a splici [...] (536 aa)
0.991
EP300
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
0.988
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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