STRING 9.05 






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Your Input:
RORA
RAR-related orphan receptor A; Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one [...] (556 aa)
(Homo sapiens)
Predicted Functional Partners:
ARNTL
aryl hydrocarbon receptor nuclear translocator-like; ARNTL-CLOCK heterodimers activate E-box el [...] (625 aa)
0.976
NPAS2
neuronal PAS domain protein 2; BMAL1-NPAS2 heterodimers activate E-box element (3'- CACGTG-5') [...] (824 aa)
0.976
EP300
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
0.975
NCOA2
nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear r [...] (1464 aa)
0.965
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member [...] (483 aa)
0.959
CLOCK
clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transc [...] (846 aa)
0.958
MEF2C
myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 elemen [...] (473 aa)
0.914
CREBBP
CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation [...] (2442 aa)
0.914
NR1D1
nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional re [...] (614 aa)
0.914
CARM1
coactivator-associated arginine methyltransferase 1; Methylates (mono- and asymmetric dimethyla [...] (608 aa)
0.914
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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