| Your Input: |
 | NR1H4 | nuclear receptor subfamily 1, group H, member 4; Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus (472 aa) |
| | (Homo sapiens) |
Predicted Functional Partners: |
 | RXRA | retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa) | 0.985 |
 | CYP7A1 | cytochrome P450, family 7, subfamily A, polypeptide 1 (504 aa) | 0.965 |
 | NR0B2 | nuclear receptor subfamily 0, group B, member 2; Acts as a negative regulator of receptor-depen [...] (257 aa) | 0.965 |
 | FABP6 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen [...] (177 aa) | 0.954 |
 | ABCB11 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretio [...] (1321 aa) | 0.954 |
 | CYP8B1 | cytochrome P450, family 8, subfamily B, polypeptide 1; Involved in bile acid synthesis and is r [...] (501 aa) | 0.946 |
 | SLC10A1 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/ [...] (349 aa) | 0.946 |
 | GPS2 | G protein pathway suppressor 2; Suppresses G-protein- and mitogen-activated protein kinase-medi [...] (327 aa) | 0.927 |
 | ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4; Mediates ATP-dependent export of organi [...] (1286 aa) | 0.927 |
 | NCOA1 | nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear recept [...] (1441 aa) | 0.919 |
Permalink