STRING 9.05 






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This is the confidence view. Stronger associations are represented by thicker lines.

 
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Your Input:
NR1H3
nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis (447 aa)
(Homo sapiens)
Predicted Functional Partners:
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
0.994
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1; cAMP-dependent and sulfonylurea-sensitive [...] (2261 aa)
0.965
RXRG
retinoid X receptor, gamma; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (463 aa)
0.905
RXRB
retinoid X receptor, beta; Nuclear hormone receptor. Involved in the retinoic acid response pat [...] (533 aa)
0.905
NR1H2
nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to doubl [...] (460 aa)
0.903
FASN
fatty acid synthase; Fatty acid synthetase catalyzes the formation of long- chain fatty acids f [...] (2511 aa)
0.893
NR0B2
nuclear receptor subfamily 0, group B, member 2; Acts as a negative regulator of receptor-depen [...] (257 aa)
0.861
REN
renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)
0.828
NRIP1
nuclear receptor interacting protein 1; Modulates transcriptional activation by steroid recepto [...] (1158 aa)
0.724
SREBF2
sterol regulatory element binding transcription factor 2; Transcriptional activator required fo [...] (1141 aa)
0.720
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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