STRING 9.05 






An error occurred.
Please check that you have installed Adobe Flash Player (version 10 or above) on your computer.
If the error still persists please contact our support center.

For info, visit http://get.adobe.com/flashplayer/





 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
 (requires Flash player 10 or better)   
Your Input:
PPARA
peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activ [...] (468 aa)
(Homo sapiens)
Predicted Functional Partners:
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
    0.997
NCOR1
nuclear receptor co-repressor 1; Mediates transcriptional repression by certain nuclear recepto [...] (2440 aa)
      0.996
NCOA1
nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear recept [...] (1441 aa)
     0.996
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1; cAMP-dependent and sulfonylurea-sensitive [...] (2261 aa)
      0.990
APOA5
apolipoprotein A-V; Minor apolipoprotein mainly associated with HDL and to a lesser extent with [...] (366 aa)
      0.988
NCOR2
nuclear receptor co-repressor 2; Mediates the transcriptional repression activity of some nucle [...] (2521 aa)
     0.986
EP300
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
     0.986
PLIN2
perilipin 2; May be involved in development and maintenance of adipose tissue (By similarity) (437 aa)
      0.985
CLOCK
clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transc [...] (846 aa)
      0.984
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functi [...] (826 aa)
      0.983
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (3%)
Permalink