Home  •  Download  •  Help  •  My Data 
 STRING 9.05 






An error occurred.
Please check that you have installed Adobe Flash Player (version 10 or above) on your computer.
If the error still persists please contact our support center.

For info, visit http://get.adobe.com/flashplayer/





 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
 (requires Flash player 10 or better)   
Your Input:
PPARD
peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (441 aa)
(Homo sapiens)
Predicted Functional Partners:
CREBBP
CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation [...] (2442 aa)
     •• 0.925
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)
     •• 0.911
ESR1
estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are inv [...] (595 aa)
     •••0.908
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
     •••0.907
HNF4A
hepatocyte nuclear factor 4, alpha; Transcriptionally controlled transcription factor. Binds to [...] (474 aa)
     •••0.904
RXRG
retinoid X receptor, gamma; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (463 aa)
     •••0.904
ESRRA
estrogen-related receptor alpha; Binds to an ERR-alpha response element (ERRE) containing a sin [...] (423 aa)
     •••0.904
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avia [...] (490 aa)
     •••0.903
PPARG
peroxisome proliferator-activated receptor gamma; Receptor that binds peroxisome proliferators [...] (505 aa)
     •••0.903
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor; Nuclear hormone receptor. Transcription factor [...] (427 aa)
     •••0.903
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes
 Server load: low (7%)
Share
Permalink