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 STRING 9.05 






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This is the evidence view. Different line colors represent the types of evidence for the association.

 
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Your Input:
PPARD
peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (441 aa)
(Homo sapiens)
Predicted Functional Partners:
CREBBP
CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation [...] (2442 aa)
     •• 0.925
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)
     •• 0.911
ESR1
estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are inv [...] (595 aa)
     •••0.908
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
     •••0.907
HNF4A
hepatocyte nuclear factor 4, alpha; Transcriptionally controlled transcription factor. Binds to [...] (474 aa)
     •••0.904
RXRG
retinoid X receptor, gamma; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (463 aa)
     •••0.904
ESRRA
estrogen-related receptor alpha; Binds to an ERR-alpha response element (ERRE) containing a sin [...] (423 aa)
     •••0.904
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avia [...] (490 aa)
     •••0.903
PPARG
peroxisome proliferator-activated receptor gamma; Receptor that binds peroxisome proliferators [...] (505 aa)
     •••0.903
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor; Nuclear hormone receptor. Transcription factor [...] (427 aa)
     •••0.903
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes
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