NR3C2 protein (Homo sapiens) - STRING network view

STRING 9.05

This is the confidence view. Stronger associations are represented by thicker lines.




confidence	evidence	actions	interactive	advanced	more	less	save

(requires Flash player 10 or better)

Your Input:
	NR3C2	nuclear receptor subfamily 3, group C, member 2; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (984 aa)
		(Homo sapiens)
Predicted Functional Partners:
	TRIM24	tripartite motif-containing 24; Interacts selectively in vitro with the AF2-activating domain o [...] (1050 aa)	0.878
	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), m [...] (491 aa)	0.811
	HSD17B6	hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with bro [...] (317 aa)	0.752
	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2; Catalyzes the conversion of cortisol to the inactive [...] (405 aa)	0.752
	REN	renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)	0.752
	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)	0.729
	FKBP4	FK506 binding protein 4, 59kDa; Component of unactivated mammalian steroid receptor complexes t [...] (459 aa)	0.676
	HSPA4	heat shock 70kDa protein 4 (840 aa)	0.661
	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); Receptor for glucoco [...] (778 aa)	0.654
	CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2; Preferentially catalyzes the conversion [...] (503 aa)	0.651

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes

Server load: low (1%)

Permalink