STRING 9.05 






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This is the confidence view. Stronger associations are represented by thicker lines.

 
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Your Input:
NR1H4
nuclear receptor subfamily 1, group H, member 4; Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus (472 aa)
(Homo sapiens)
Predicted Functional Partners:
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
0.985
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1 (504 aa)
0.965
NR0B2
nuclear receptor subfamily 0, group B, member 2; Acts as a negative regulator of receptor-depen [...] (257 aa)
0.965
FABP6
fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen [...] (177 aa)
0.954
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretio [...] (1321 aa)
0.954
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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