STRING 9.05 
  ESRRA protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ESRRA
estrogen-related receptor alpha; Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism (423 aa)
(Homo sapiens)
Predicted Functional Partners:
ESRRG
estrogen-related receptor gamma; Orphan receptor that acts as transcription activator in the ab [...] (458 aa)
    0.993
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Transcriptional coactiva [...] (798 aa)
      0.983
ESR1
estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are inv [...] (595 aa)
    0.963
NRIP1
nuclear receptor interacting protein 1; Modulates transcriptional activation by steroid recepto [...] (1158 aa)
      0.945
NR0B2
nuclear receptor subfamily 0, group B, member 2; Acts as a negative regulator of receptor-depen [...] (257 aa)
      0.932
PPARG
peroxisome proliferator-activated receptor gamma; Receptor that binds peroxisome proliferators [...] (505 aa)
     0.913
PPARA
peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key re [...] (468 aa)
     0.911
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avia [...] (490 aa)
     0.907
RORA
RAR-related orphan receptor A; Orphan nuclear receptor. Binds DNA as a monomer to hormone respo [...] (556 aa)
     0.906
NR2F6
nuclear receptor subfamily 2, group F, member 6 (404 aa)
     0.904
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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