STRING 9.05 
  NR1H4 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NR1H4
nuclear receptor subfamily 1, group H, member 4; Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus (472 aa)
(Homo sapiens)
Predicted Functional Partners:
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
    0.985
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1 (504 aa)
       0.965
NR0B2
nuclear receptor subfamily 0, group B, member 2; Acts as a negative regulator of receptor-depen [...] (257 aa)
      0.965
FABP6
fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen [...] (177 aa)
       0.954
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretio [...] (1321 aa)
       0.954
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1; Involved in bile acid synthesis and is r [...] (501 aa)
       0.946
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/ [...] (349 aa)
       0.946
GPS2
G protein pathway suppressor 2; Suppresses G-protein- and mitogen-activated protein kinase-medi [...] (327 aa)
      0.927
ABCB4
ATP-binding cassette, sub-family B (MDR/TAP), member 4; Mediates ATP-dependent export of organi [...] (1286 aa)
       0.927
NCOA1
nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear recept [...] (1441 aa)
      0.919
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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